Originally Posted by BIGPOPPA
maybe take a break from smoking for a couple days. Ive noticed that if ive been smoking daily plus my usual snuffing i start to not feel well after about a week. I think the nicotine built up faster than my body could get rid of it and i was starting to feel sick from it. After a couple days i was fine.
If your not drinking enough fluids your body might not be able to flush the nicotine from your body quick enough. I read somewhere that the nicotine tends to gravitate to the liver so it may take some time for it to process it out.
That you are right BP...
"As nicotine enters the body, it is distributed quickly through the bloodstream
and can cross the blood-brain barrier
. On average it takes about seven seconds for the substance to reach the brain
when inhaled[citation needed
]. The half life
of nicotine in the body is around two hours.
The amount of nicotine absorbed by the body from smoking depends on many factors, including the type of tobacco, whether the smoke is inhaled, and whether a filter is used. For chewing tobacco
, dipping tobacco
, which are held in the mouth between the lip and gum, or taken in the nose, the amount released into the body tends to be much greater than smoked tobacco. Nicotine is metabolized
in the liver
by cytochrome P450
enzymes (mostly CYP2A6
, and also by CYP2B6
). A major metabolite is cotinine
Other primary metabolites include nicotine N'-oxide, nornicotine, nicotine isomethonium ion, 2-hydroxynicotine and nicotine glucuronide.
Gluconuration and oxidative metabolism of nicotine to cotinine are both inhibited by menthol
, an additive to mentholated cigarettes
, thus increasing the half-life of nicotine in vivo"